Superselective Targeting Using Multivalent Polymers
نویسندگان
چکیده
منابع مشابه
Superselective Targeting Using Multivalent Polymers
Despite their importance for material and life sciences, multivalent interactions between polymers and surfaces remain poorly understood. Combining recent achievements of synthetic chemistry and surface characterization, we have developed a well-defined and highly specific model system based on host/guest interactions. We use this model to study the binding of hyaluronic acid functionalized wit...
متن کاملSelective tumor cell targeting using low-affinity, multivalent interactions.
This report highlights the advantages of low-affinity, multivalent interactions to recognize one cell type over another. Our goal was to devise a strategy to mediate selective killing of tumor cells, which are often distinguished from normal cells by their higher levels of particular cell surface receptors. To test whether multivalent interactions could lead to highly specific cell targeting, w...
متن کاملInteractions between charged surfaces mediated by stiff, multivalent zwitterionic polymers.
The interaction between like-charged objects in electrolyte solutions can be heavily altered by the presence of multivalent ions which possess a spatially distributed charge. In this work, we examine the influence of stiff, multivalent zwitterionic polymers on the interaction between charged surfaces using a splitting field theory previously shown to be accurate for the weak to the intermediate...
متن کاملOptimizing the Selectivity of Surface-Adsorbing Multivalent Polymers
Multivalent polymers are macromolecules containing multiple chemical moieties designed to bind to complementary moieties on a target; for example, a protein with multiple ligands that have affinity for receptors on a cell surface. Though the individual ligand-receptor bonds are often weak, the combinatorial entropy associated with the different possible ligand-receptor pairs leads to a binding ...
متن کاملTargeting Cancer Cells with Polymers
Yangyang Liu Advisor: Professor Hong-Cai Zhou March 28, 201
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2014
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja411138s